Analysis ofpregnancy outcome of artificial insemination with donor sperm by different follicular size
ZHANG Yixin, ZHAO Qing, GUO Wei, GUO Xufang, ZHANG Nuo, ZHU Xuting, MA Jing, GAO Yu, WANG Xiu
The Reproductive Health Guidance Center ofHebei Province Family Planning Science and Technology Institute(Key Laboratory of Family Planning and Health Birth, National Health and Family Planning Comission ),Shijiazhuang 050071, China
Abstract：Objective To explore the effects of follicular factors to the artificial insemination with donor sperm (AID) and to improve the clinical pregnancy rate of AID. Methods A total of 1 616 cycles from 704 infertility couples who received AID assisted treatment and used intrauterine insemination(IUI) in the Department of Reproductive Medicine of Hebei province during January and December 2016, were observed. The pregnancy outcomes by different follicle size were analyzed. Results The clinical pregnancy rate was 29.5% (477/1616).The cumulative pregnancy rate was 67.8% (477/704) and the abortion rate was 11.7% (56/477). The highest clinical pregnancy rate was 31.5% (181/574), which was the group of 18 mm≤ the follicle diameter<20 mm, followed by 29.5% (176/596) in the group of 16 mm≤ the follicle diameter<18 mm, the rate showed decreasing while 20 mm≤ the follicle diameter <22 mm, while there’s no significant difference between groups. Pregnancy rate among stimulate ovulation cycle was higher than the natural period with no statistically significant difference. The pregnancy rate was significantly higher in the woman ≤35 years old group than the woman > 35 years old group, regardless the group of 18 mm≤ the follicle diameter <20 mm or the group of 20 mm≤ the follicle diameter <22 mm. Conclusion Based on the current analysis on the pregnancy outcome of AID with different follicular size, our study indicated that patients with follicle diameter from 16mm to 18mm could try to promote follicular growth and ovulation and should not give up intrauterine insemination (IUI), especially for the patients aged 35 years and older. Positive treatment measures should be considered besides the influence of age. To improve the egg quality and improve the clinical pregnancy rate of the infertility patients with follicular dysplasia, we could take preventive measures in advance in the next cycle, choose personalized treatment plan, and give ovulation induction treatment timely.
