1 van der Bom T,Zomer AC,Zwinderman AH,et al.The changing epidemiology of congenital heart disease.Nat Rev Cardiol,2011,8:50-60.
2 Liu S,Joseph KS,Lisonkova S,et al.Association between maternal chronic conditions and congenital heart defects:a population-based cohort study.Circulation,2013,128:583-589.
3 Padula AM,Tager IB,Carmichael SL,et al.Ambient air pollution and traffic exposures and congenital heart defects in the San Joaquin Valley of California.Paediatr Perinat Epidemiol,2013,27:329-339.
4 Fung A,Manlhiot C,Naik S,et al.Impact of prenatal risk factors on congenital heart disease in the current era.J Am Heart Assoc,2013,2:e000064.
5 Gelb BD.Recent advances in understanding the genetics of congenital heart defects.Curr Opin Pediatr,2013,25:561-566.
6 Tan M,Xu C,Sim SK,et al.Types and distribution of congenital heart defects associated with trisomy 21 in Singapore.J Paediatr Child Health,2013,49:223-227.
7 Polli JB,Groff Dde P,Petry P,et al.Trisomy 13 (Patau syndrome) and congenital heart defects.Am J Med Genet A,2014,164A:272-275.
8 Cooper GM,Coe BP,Girirajan S,et al.A copy number variation morbidity map of developmental delay.Nat Genet,2011,43:838-846.
9 Yan Y,Wu Q,Zhang L,et al.Detection of submicroscopic chromosomal aberrations by array-based comparative genomic hybridization in fetuses with congenital heart disease.Ultrasound Obstet Gynecol,2014,43:404-412.
10 Bansal V,Dorn C,Grunert M,et al.Outlier-Based Identification of Copy Number Variations Using Targeted Resequencing in a Small Cohort of Patients with Tetralogy of Fallot.PLoS One,2014,9:e85375.
11 Joziasse IC,van de Smagt JJ,Smith K,et al.Genes in congenital heart disease:atrioventricular valve formation.Basic Res Cardiol.2008,103:216-327.
12 Pang S,Liu Y,Zhao Z,et al.Novel and functional sequence variants within the TBX2 gene promoter in ventricular septal defects.Biochimie,2013,95:1807-1809.
13 Wall NA,Craig EJ,Labosky PA,et al.Mesendoderm induction and reversal of left-right pattern by mouse Gdf1,a Vg1-related gene.Dev Biol,2000,227:495-509.
14 Lee SJ.Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily.Mol Endocrinol,1990,4:1034-1040.
15 Lee SJ.Expression of growth/differentiation factor 1 in the nervous system:conservation of a bicistronic structure.Proc Natl Acad Sci U S A,1991,88:4250-4254.
16 Tanaka C,Sakuma R,Nakamura T,et al.Long-range action of Nodal requires interaction with GDF1.Genes Dev,2007,21:3272-3282.
17 Rankin CT,Bunton T,Lawler AM,et al.Regulation of left-right patterning in mice by growth/differentiation factor-1.Nat Genet,2000,24:262-265.
18 Torlopp A,Khan MA,Oliveira NM,et al.The transcription factor Pitx2 positions the embryonic axis and regulates twinning.Elife,2014,3:e03743.
19 Li X,Ma Y,Li D,et al.Arsenic impairs embryo development via down-regulating Dvr1 expression in zebrafish.Toxicol Lett,2012,212:161-168.
20 Fuerer C,Nostro MC,Constam DB.Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.J Biol Chem,2014,289:17854-17871.
21 Karkera JD,Lee JS,Roessler E,et al.Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans.Am J Hum Genet,2007,81:987-994.
22 Kaasinen E,Aittom ki K,Eronen M,et al.Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).Hum Mol Genet,2010,19:2747-2753.
23 Sun X,Meng Y,You T,et al.Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population.Mol Biol Rep,2013,40:1291-1299.
24 De Luca A,Sarkozy A,Consoli F,et al.Familial transposition of the great arteries caused by multiple mutations in laterality genes.Heart,2010,96:673-677.
25 De Luca A,Sarkozy A,Ferese R,et al.New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.Clin Genet,2011,80:184-190.
26 Shen MM.Nodal signaling:Developmental roles and regulation.Development,2007,134:1023-1034.
27 Schier AF,Shen MM.Nodal signalling in vertebrate development.Nature,2000,403:385-389.
28 Roessler E,Ouspenskaia MV,Karkera JD,et al.Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.Am J Hum Genet,2008,83:18-29.
29 Andersson O,Reissmann E,J rnvall H,et al.Synergistic interaction between Gdf1 and Nodal during anterior axis development.Dev Biol,2006,293:370-381.
30 Zhang XM,Ramalho-Santos M,McMahon AP.Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.Cell,2001,105:781-792.
31 Kitajima K,Oki S,Ohkawa Y,et al.Wnt signaling regulates left-right axis formation in the node of mouse embryos.Dev Biol,2013,380:222-232.
