Abstract：Objective To evaluate dynamic changes of serum HBV markers after combined vaccination in neonates born to HBV positive mothers.Methods 193 newborns were intramuscular injected with HBIG 200 U within 12 hours after birth. Meanwhile, those newborns were intramuscular injected with HBVac 10ug on other position. Venous blood samples of the newborns were collected and tested for HBVM and HBV DNA at birth, and at 6th, 12th, and 18th month after birth, respectively.Results At birth, HBsAg positive rate was 16.6%. HBV intrauterine infection rate was 3.6%. For HbeAg positive mothers, their baby’s HBeAg positive rate was 95.2% at birth. After intramuscular injection in combination with vaccine, the infant’s HBeAg became negative at 12th month, and all infant’s HBcAb was positive at birth; at 18th month, the positive rate was 27.1%. For HBeAb positive mothers, their baby’s HBeAb positive rate was 100% at birth. After combined vaccination, the infant’s HBeAb became negative at 12 monthth; all infant’s HBcAb was positive at birth; at 18th month, the positive rate was 50%.Conclusion For the HBV positive mothers, if their babies’ HBVM was HBeAg, HBeAb or HBcAb positive, these markers came from the mother, and do not mean HBV infection.
