Abstract：Objective To synthesize evidence on the correlation between p53 Arg72Pro polymorphism and recurrent spontaneous abortion.Methods PubMed, Cochrane, Medline, CNKI, VIP, and WanFang Data were searched from inception to December, 2015 to collect studies on the correlation between p53 Arg72Pro polymorphism and recurrent spontaneous abortion. The studies were screened according to the predefined inclusion and exclusion criteria by two researchers independently. The quality of each report was evaluated, the data were extracted, and then meta-analysis was performed using RevMan 5.3 software.Results A total of 7 case-control studies involving 991 cases and 913 controls were identified. The results of meta-analysis showed that p53 Arg72Pro polymorphism was associated with an increased risk of recurrent spontaneous abortion (Pro/Pro vs Arg/Pro+Arg/Arg:OR=2.22, 95%CI:1.27-3.89; Pro/Pro vs Arg/Arg:OR=2.23, 95% CI:1.05-4.73; Pro/Pro vs Arg/Pro:OR=1.89, 95%CI:1.36-2.64).Conclusion The p53 Arg72Pro polymorphism is associated with an elevated risk of recurrent spontaneous abortion.
1 Saravelos SH,Cocksedge KA,Li TC.The pattern of pregnancy loss in women with congenital uterine anomalies and recurrent miscarriage.Reprod Biomed Online,2010,20:416- 422. 2 Banch DW,Gibson M,Silver RM.Clinical practice.Recurrent miscarriage.N Engl J Med,2010,363:1740-1747. 3 叶喜阳,徐宏里,黄文青.反复自然流产患者血清及胎盘绒毛组织中细胞因子的研究.中国妇幼保健,2006,21:2132-2134. 4 Li Z,Ni M,Li J, et al.Decision making of the p53 network:Death by integration.J Theor Biol,2011,271:205-211. 5 Thomas M,Kalita A,Labrecque S,et al.Two polymorphic variants of wild-type p53 differ biochemically and biologically.Mol Cell Biol,1999,19:1092-1100. 6 Pietrowski D,Bettendorf H,Riener EK,et al.Recurrent pregnancy failure is associated with a polymorphism in the p53 tumor suppressor gene.Hum Reprod,2005,20:848-851. 7 Kay C,Jeyendran RS,Coulam CB.p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure.Reprod Biomed Online,2006,13:492-496. 8 Firouzabadi RD,Ghasemi N,Rozbahani MA, et al.Association of p53 polymorphism with ICSI/IVF failure and recurrent p regnancy loss.Aust N Z J Obstet Gynaecol,2009,49:216-219. 9 Kaare M,Butzow R,Ulander VM,et al.Study of p53 gene mutations and placental expression in recurrent miscarriage cases.Reprod Biomed Online,2009,18:430-435. 10 Tang W,Zhou X,Chan Y,et al.p53 codon 72 polymorphism and recurrent pregnancy loss:a meta-analysis.J Assist Reprod Genet,2011,28:965-969. 11 Su M,Lin S,Chen Y.Genetic association studies of angiogenesis- and vasoconstriction-related genes in women with recurrent pregnancy loss:a systematic review and meta-analysis.Hum Reprod Update,2011,17:803-812. 12 Fraga LR,Dutra CG,Boquett JA,et al.p53 signaling pathway polymorphisms associated to recurrent pregnancy loss.Mol Biol Rep,2014,41:1871-1877. 13 Lledo B,Turienzo A,Ortiz JA,et al.Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss.J Assist Reprod Genet,2014,31:169-172. 14 Coulam CB,Kay C,Jeyendran RS.Role of p53 codon 72 polymorphism in recurrent pregnancy loss.Reprod Biomed Online,2006,12:378-382. 15 Sang Ho Yoon,Young Min Choi,Jin Ju Kim, et al.No association of p53 codon 72 polymorphism with idiopathic recurrent pregnancy loss in Korean population.Eur J Obstetr Gynecold Reprod Biol,2015,192:6-9. 16 Little J,Higgins JP,Ioannidis JP,et al.Strengthening the Reporting of Genetic Association Studies(STREGA):an extension of the STROBE statement.PloS Med,2009,6:e22. 17 曾铮,周晓军.膀胱癌分子标记物.医学研究生学报,2009,22:1333-1336. 18 Storey JD.A direct approach to false discovery rates.J R Statist Soc B,2002,64:479-498. 19 黄郁馨.p53基因rs1042522位点基因多态性与中国汉族妇女子官内膜异位症易感性的关联研究及相关文献的mete分析.广州:南方医科大学,2013. 20 Kang,HJ,Feng Z,Sun Y,et al.Single-niicleotide polymorphisms in the p53 pathway regulate fertility in humans.Proc Natl Acad Sci USA,2009,106:9761-9766. 21 方燕.p53,MDM2基因及其多态与稽留流产的关系研究.山东:山东大学,2009. 22 Dumont PJ,Leu LJ,Delia Pietra AC,et al.The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.Nat Genet,2003,33:357-365. 23 Sullivan A,Syed N,Gasco M,et al.Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo.Oncogene,2004,23:3328-3337. 24 Wei D,Wu Q,Shi H.Apoptosis and p53 expression in the placental villi of females with unexplained recurrent spontaneous abortion.Exp Ther Med,2014,7:191-194. 25 Balint EE,Vousden KH.Activation and activities of the p53 tumour suppressor protein.Br J Cancer,2001,85:1813-1823. 26 Zhang Y,Xiong Y.A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation.Science,2001,292:1910-1915. 27 Moyer P.Race,weight,and smoking status may influence p53 positive breast cancer.Am Assoc Cancer Res,2005,286:38-45.
