同种免疫型复发性流产的病因学研究及治疗进展

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摘要复发性流产 (RSA)是指同一对夫妇连续发生2次或2次以上的20周内自然流产,其免疫学病因包括自身免疫型及同种免疫型。同种免疫型RSA主要通过排除法诊断,即不明原因的复发性流产,约占免疫型RSA的2/3,应重点关注。本文检索中国知网、ScienceDirect、PubMed等数据库的有关文献,对同种免疫型RSA的病因及治疗进行系统地复习,发现该病主要与母胎免疫耐受失衡有关,治疗上可通过主动与被动免疫弥补RSA患者母胎之间的保护性抗体,或改善淋巴细胞亚群的表达,平衡母胎免疫耐受。但大部分治疗用药的安全性及可行性缺乏大样本的临床研究,用药方案有待进一步完善并形成共识。

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	郑晶
	崔慧
	孙丽
	刘春娜

关键词 ：复发性流产, 同种免疫型, 病因, 治疗进展

收稿日期: 2019-01-28

通讯作者: 崔慧(492262487@qq.com)

引用本文:

郑晶, 崔慧, 孙丽, 刘春娜. 同种免疫型复发性流产的病因学研究及治疗进展[J]. 中国生育健康杂志, 2020, 31(6): 590-593.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2020/V31/I6/590

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