Association between dietary frequency and Stannum level in hair of pregnant women with gestational diabetes mellitus and healthy women in Haidian district, Beijing
JIA Xiaoqian, REN Mengyuan, YANG Haishan, WANG Bin, ZHANG Le, WANG Jiamei, LI Zewu, LIU Shuyu, LI Zhiwen, LIU Xiaohong
Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China
Abstract：Objective To describe and compare the concentration of Stannum(Sn) in the hair of gestational diabetes mellitus (GDM) women and healthy pregnant women in Haidian district of Beijing, and explore the relationship between Sn and dietary intake frequency. Methods Subjects were early pregnant women who filed in the Haidian District Maternal and Child Health Hospital in Beijing from October 2017 to October 2018 and volunteered to participate in the birth cohort. Questionnaires were used to collect general demographic characteristics and dietary frequency, and hair samples were also collected. A 75-g oral glucose tolerance test was performed between 24-28 weeks of pregnancy. This study was a nested case-control design. The control group was randomly selected according to the ratio of case∶control=1∶1. A total of 338 cases and 343 controls were included in analysis. Sn in hair was detected by inductively coupled plasma mass spectrometer. Results Sn concentrations (median) of GDM group and control group were 0.17 μg/g and 0.14 μg/g, respectively. Sn was significantly higher in GDM group than control group; there was no significant difference of Sn concentration distribution among different groups in the case or control group. Eating fried foods is a risk factor for Sn exposure, while meat, seafood, fresh vegetables, fresh fruits, barbecue, preserved foods, desserts and carbonated beverages were not related to Sn. Conclusion Sn exposure of pregnant women in Haidian district of Beijing was relatively lower, but Sn of GDM group was higher than that of control group. Eating fried food was a risk factor for Sn exposure, and no other dietary intake frequency were found to be related to Sn exposure of pregnant women.
贾晓倩, 任梦圆, 杨海珊, 王斌, 张乐, 王佳楣, 李泽武, 刘淑玉, 李智文, 刘晓红. 北京市海淀区妊娠期糖尿病和健康孕妇膳食频次与头发中锡水平的关联研究[J]. 中国生育健康杂志, 2021, 32(3): 201-205.
JIA Xiaoqian, REN Mengyuan, YANG Haishan, WANG Bin, ZHANG Le, WANG Jiamei, LI Zewu, LIU Shuyu, LI Zhiwen, LIU Xiaohong. Association between dietary frequency and Stannum level in hair of pregnant women with gestational diabetes mellitus and healthy women in Haidian district, Beijing. Chinese Journal of Reproductive Health, 2021, 32(3): 201-205.
1 Hectors TL,Vanparys C,van der Ven K,et al.Environmental pollutants and type 2 diabetes:a review of mechanisms that can disrupt beta cell function.Diabetologia,2011,54:1273-1290. 2 韩磊,张恒东.铅、镉的毒性及其危害.职业卫生与病伤,2009,24:173-177. 3 WHO.Trace elements in human nutrition and health.1996.Available at http://www.who.int/nutrition/publications/micronutrients/9241561734/en/.Accessed on 2020/01/10. 4 Blunden S,Wallace T.Tin in canned food:a review and understanding of occurrence and effect.Food Chem Toxicol,2003,41:1651-1662. 5 Airaksinen R,Rantakokko P,Turunen AW,et al.Organotin intake through fish consumption in Finland.Environ Res,2010,110:544-547. 6 Boogaard PJ,Boisset M,Blunden S,et al.Comparative assessment of gastrointestinal irritant potency in man of tin(II) chloride and tin migrated from packaging.Food Chem Toxicol,2003,41:1663-1670. 7 Heindel JJ,Blumberg B,Cave M,et al.Metabolism disrupting chemicals and metabolic disorders.Reprod Toxicol,2017,68:3-33. 8 Rantakokko P,Main KM,Wohlfart-Veje C,et al.Association of placenta organotin concentrations with congenital cryptorchidism and reproductive hormone levels in 280 newborn boys from Denmark and Finland.Hum Reprod,2013,28:1647-1660. 9 Feng W,Cui X,Liu B,et al.Association of urinary metal profiles with altered glucose levels and diabetes risk:a population-based study in China.PloS One,2015,10:e0123742. 10 Liu B,Sun Y,Lehmler HJ,et al.Association between urinary tin concentration and diabetes in nationally representative sample of US adults.J Diabetes,2018,10:977-983. 11 Metzger BE,Gabbe SG,Persson B,et al.International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.Diabetes Care,2010,33:676-682. 12 American Diabetes Association.Standards of medical care in diabetes--2014.Diabetes Care,2014,37 :S14-80. 13 Chen YW,Lan KC,Tsai JR,et al.Tributyltin exposure at noncytotoxic doses dysregulates pancreatic β-cell function in vitro and in vivo.Arch Toxicol,2017,91:3135-3144. 14 Miura Y,Hori Y,Kimura S,et al.Triphenyltin impairs insulin secretion by decreasing glucose-induced NADP(H) and ATP production in hamster pancreatic β-cells.Toxicology,2012,299:165-171. 15 周珊珊,刘颖.内蒙古兴和县育龄妇女头发中矿质元素分布及影响因素研究.光谱学与光谱分析,2016,36:3422-3428. 16 陈小红.福建省孕妇头发化学元素含量及其相关因素与胎儿先天性心脏病关系.福建医科大学,2014. 17 Poddalgoda D,Macey K,Jayawardene I,et al.Derivation of biomonitoring equivalent for inorganic tin for interpreting population-level urinary biomonitoring data.Regul Toxicol Pharmacol,2016,81:430-436. 18 Adams WA,Xu Y,Little JC,et al.Predicting the migration rate of dialkyl organotins from PVC pipe into water.Environ Sci Technol,2011,45:6902-6907. 19 Sadiki AI,Williams DT.A study on organotin levels in Canadian drinking water distributed through PVC pipes.Chemosphere,1999,38:1541-1548. 20 李敏,王紫纹,刘佳,等.2017年北京市市售6大类罐头食品中14种元素的监测.职业与健康,2018,34:1480-1484.
