202例急性淋巴细胞白血病儿童细胞遗传学特点

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摘要目的了解急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)儿童细胞遗传学特点及其临床意义。方法收集华中科技大学同济医学院附属同济医院儿童血液科诊断的202例ALL儿童的临床资料,包括染色体、基因、性别、年龄、临床危险度及预后进行统计学分析。结果 (1)202例ALL患儿中,正常核型占67.8%,异常核型占32.2%:其中单纯数目异常者占21.5%,单纯结构异常者占35.4%,数目及结构均异常者占43.1%。融合基因阳性患儿占20.8%(42/202)。(2)染色体数目异常者中,主要为超二倍体患儿,占46.2%;结构异常中,主要为t(9;22)与t(1;19)患儿,各占9.8%;融合基因中,主要为TEL/AML1阳性患儿,占42.9%(18/42)。(3)本组ALL儿童的细胞遗传学特征与年龄、临床危险度有关,但与性别无关;(4)融合基因阳性的患儿中,仅26.2%(11/42)患儿携带对应的染色体核型。(5)截止随访时间,存活者占82.2%(166/202),死亡者占10.9%(22/202),失访者占6.9%(14/202)。染色体核型与ALL儿童预后明显相关(P<0.001)。结论不同年龄、临床危险度患儿的细胞遗传学存在明显差别,且染色体核型与预后明显相关。融合基因检测阳性率高于染色体分析。

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关键词 ：急性淋巴细胞白血病, 儿童, 染色体, 核型改变

收稿日期: 2020-12-21

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R72

通讯作者: 胡群(qunhu2013@163.com)

引用本文:

尹萌萌, 刘爱国, 张艾, 王雅琴, 胡群. 202例急性淋巴细胞白血病儿童细胞遗传学特点[J]. 中国生育健康杂志, 2022, 33(5): 474-478.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2022/V33/I5/474

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