双胎妊娠的子痫前期预测研究进展

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摘要子痫前期(PE)是孕产妇死亡、孕产妇与围产儿不良结局发生的重要因素。双胎妊娠PE的发病率更高,据报道可达13%~37%。与单胎妊娠不同,双胎妊娠可能因胎盘较大、胎盘分泌的血管因子更多,而存在特殊的PE发生机制,临床上也表现出发病时间早而严重合并症较少的特点。双胎妊娠PE特殊的高危因素包括绒毛膜性、IVF妊娠、胎儿生长不一致等。目前针对双胎妊娠PE的预测研究多集中于单一的血清学检查,如磷脂酰肌醇糖生物合成类F蛋白(PIGF)、可溶性血管内皮生长因子受体-1(sFlt-1)、妊娠相关血浆蛋白A(PAPP-A),或子宫动脉多普勒超声指标监测,而综合多因素建立的预测模型相对较少,预测效果仍需校准,且研究多存在样本量不足等缺陷,因此需要更多的多中心大样本研究以辅助临床决策。

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	唐天一
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	赵扬玉

关键词 ：双胎妊娠, 子痫前期, 预测, 预测模型

收稿日期: 2021-01-05

ZTFLH:	R17
	R71

通讯作者: 赵扬玉(zhaoyangyu001@163.com)

引用本文:

唐天一, 魏瑗, 赵扬玉. 双胎妊娠的子痫前期预测研究进展[J]. 中国生育健康杂志, 2023, 34(1): 98-102.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2023/V34/I1/98

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