Abstract：Objective To analyze the clinical presentations as well as diagnosis and treatments of community acquired respiratory infections in neonates, and explore appropriate anti-infection therapeutic strategies in a tertiary hospital.Methods Neonates with community-acquired respiratory infection admitted to the neonate center of the study hospital were included in this retrospective study. Clinical features, pathogens, treatment, and prognosis of the patients were described, and the differences in typical characteristics were compared between patients with viral infection and those with bacterial infection.Results In total, 49 neonates were included. The detection rate of respiratory virus infection was 59.2%(29/49), in which respiratory syncytial virus accounted for 80.7%(21/26). The detection rate of respiratory bacterial infections was 18.4%(9/49), and the detection rate of respiratory virus combined with bacterial infections was 4.1%(2/49). Compared to patient with the bacterial infection, those with viral infection had a higher proportion of positive contact history(76.9% vs 30.0%, P<0.05) and a lower proportion of fever symptoms(23.1% vs 60.0%, P=0.053). Antibiotics was used in 26.5% of the patients, and there was a significant difference between patients with viral infection and those with bacterial infection(0 vs 100%, P<0.05); there was no significant difference in NICU admission rates between the two groups(11.5% vs 20.0%, P>0.05), and all neonates admitted to NICU were either cured or improved. The readmission rate within 7 days was 0. All patients with respiratory virus infection received respiratory isolation, with a respiratory virus infection rate of 0.Conclusion The implementation of standardized clinical management plans for community-acquired pneumonia in neonates can effectively differentiate and refine the diagnosis and treatments, reduce the proportion and duration of antibiotic use, and improve standardized use of antibiotics. Selection of antibiotics based on infection control monitoring, clear standards for introduction and withdrawal of antibiotics, accurate and timely detection of pathogens, community respiratory contact history, and respiratory disease infection control in neonatal wards are important in the diagnosis and treatment of community-acquired respiratory tract infections in newborns.
黄鸿眉, 徐晨光, 黄海波, 薛银, 易艳芝. 新生儿社区获得性呼吸道感染诊疗路径单中心实践研究[J]. 中国生育健康杂志, 2024, 35(1): 24-28.
HUANG Hongmei, XU Chenguang, HUANG haibo, XIE Yin, YI Yanzi. The practice of clinical pathway for community-acquired respiratory tract infection in neonates in a single tertiary hospital. Chinese Journal of Reproductive Health, 2024, 35(1): 24-28.
