Median effective dose of dexmedetomidine on responses to extubation during recovery from general anesthesia in preeclampsia patients undergoing cesarean section
WANG Wenkai, ZHAN Hong
Department of Anesthesiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
Abstract：Objective To determine the median effective dose (ED50) of dexmedetomidine inhibiting responses to extubation during recovery from general anesthesia in preeclampsia patients undergoing cesarean section.Methods This study included one hundred ASA physical status II or III patients with preeclampsia scheduled for cesarean section under general anesthesia. All patients were divided into 2 groups: mild preeclampsia (group I, n=50) and severe preeclampsia (group II, n=50). The initial dose of dexmedetomidine was 0.5 μg/kg and the ratio between the two successive doses was 1.2. The dose was increased/decreased in the next patient. Dexmedetomidine was infused intravenously over 15 min after fetal disengagement. The response to extubation was defined as positive when systolic blood pressure rose 25% above baseline values and maintained at this level for more than 1 min. The ED50 and 95% confidence interval (CI) were calculated by probit analysis.Results The ED50 (95% CI) of inhibiting responses to extubation was 0.5 μg/kg (0.4~0.5 μg/kg) in group I and 0.6 μg/kg (0.6~0.7 μg/kg) in group II.Conclusion The ED50 of dexmedetomidine inhibiting responses to extubation during recovery from general anesthesia was 0.5 μg/kg and 0.6 μg/kg, respectively, in mild and severe preeclampsia patients undergoing cesarean section.
王文凯, 詹鸿. 右美托咪定抑制子痫前期剖宫产患者全身麻醉恢复期气管拔管反应的半数有效剂量[J]. 中国生育健康杂志, 2016, 27(3): 222-225.
WANG Wenkai, ZHAN Hong. Median effective dose of dexmedetomidine on responses to extubation during recovery from general anesthesia in preeclampsia patients undergoing cesarean section. Chinese Journal of Reproductive Health, 2016, 27(3): 222-225.
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