Relationships of nine element concentrations in umbilical cord tissue and gestational age
YU Jinhui, SUN Ying, SU Zaiming, LI Zhiwen, ZHANG Le, ZHANG Yali, LIU Jufen, WANG Linlin, REN Aiguo, JIN Lei
Institute of Reproductive and Child Health, Peking University/National Health Commission Of the People’s Republic of China Key Laboratory of Reproductive Health, Peking University; School of Public Health, Peking University, Beijing 100191, China
Abstract:Objective To explore the relationships between gestational age and the concentrations of selected elements in umbilical cord tissue, such as selenium (Se), cobalt (Co), cadmium (Cd), arsenic (As), lead (Pb), nickel (Ni), molybdenum (Mo), zinc (Zn) and manganese (Mn).Methods Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to detect the concentrations of the above nine elements in dried umbilical cord tissue among 166 induced fetus or newborns with neural tube defects collected in 2004-2016. The median and interquartile range (IQR:P25,P75) were used to indicate the average element concentration. Multivariate ordinal logistic regression model was used to controlling potential confounders.Results The median and IQRs of Ni, Mo, Zn and Mn was 28.99 (20.10, 49.76) ng/g, and 26.52 (21.75, 33.11) ng/g, 52.69 (44.79, 61.78) μg/g, 0.42 (0.33, 0.55) μg/g respectively, with statistically significant difference among gestational age groups. Compare to element concentration of the umbilical cord tissues in 16-22 weeks, the OR value and the 95% CI of Ni in 38-44 weeks was 0.08 (0.02, 0.27); the corresponding OR and 95% CI of Mo in 28-32 weeks and 38-44 weeks was 2.91 (1.06, 8.02) and 5.66 (1.89-16.88), respectively; the OR value and 95% CI of Zn in 23-27 weeks and 33-37 weeks was 0.32 (0.13, 0.76) and 0.26 (0.09, 0.75); the OR value and 95% CI of Mn in 23-27 weeks, 28-32 weeks and 33-37 weeks was 0.14 (0.06, 0.37), 0.28 (0.10, 0.79) and 0.10 (0.03, 0.32). The median and IQRs of Se, Co, Cd, As, Pb was 0.56 (0.50, 0.64) μg/g, 3.47 (2.48, 5.14) ng/g, 1.33 (0.57, 3.51) ng/g, 6.33 (3.96, 9.47) ng/g and 27.32 (18.37, 50.34) ng/g, respectively; the difference of medians among groups of gestational age was not statistically significant.Conclusion The content of Zn, Mn, Mo and Ni was related to gestational age, while the content of Se, Co, Cd, As and Pb in umbilical cord did not change with gestational age.
于锦慧, 孙颖, 苏在明, 李智文, 张乐, 张亚黎, 刘菊芬, 王琳琳, 任爱国, 靳蕾. 脐带组织九种元素含量与胎龄的关系[J]. 中国生育健康杂志, 2019, 30(2): 139-143.
YU Jinhui, SUN Ying, SU Zaiming, LI Zhiwen, ZHANG Le, ZHANG Yali, LIU Jufen, WANG Linlin, REN Aiguo, JIN Lei. Relationships of nine element concentrations in umbilical cord tissue and gestational age. Chinese Journal of Reproductive Health, 2019, 30(2): 139-143.
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