孕期甲基供体营养质量指数的建立与评价

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摘要目的建立甲基供体营养质量指数,评价孕期甲基供体膳食质量。方法依托北京、山东妇幼保健机构,遵循自愿原则募集218例孕妇(孕24~30周)作为研究对象。构建以甲基供体相关营养素(蛋白质、叶酸、胆碱、维生素B₂、维生素B₆、维生素B₁₂和锌)摄入量评价为主的甲基供体营养质量指数(MNQI),用于综合评价甲基供体膳食质量。采用3天24小时膳食记录法进行调查,并计算调查对象平均每天摄入营养素情况。同时采集孕妇空腹静脉血,检测红细胞叶酸、血清同型半胱氨酸、血清维生素B₁₂等一碳单位代谢指标。自拟调查问卷,调查孕妇社会人口学特征等。结果调查对象甲基供体相关营养素摄入不足比例分别为26.8%(蛋白质)、64.1%(叶酸)、50.2%(维生素B₂)、73.7%(维生素B₆)、58.9%(维生素B₁₂)和34.9%(锌);MNQI平均得分(4.89±2.18)分,中位数为5分(P₂₅~P₇₅:3~7分)。MNQI得分与红细胞叶酸水平正相关(P<0.05),与血清同型半胱氨酸水平负相关(P<0.05)。调查对象中38.3%的孕妇甲基供体膳食质量较好(MNQI≥6)。MNQI得分与家庭经济状况有关,与家庭人均月收入3 001~6 000元/月组相比,≥6 001元/月组的MNQI得分显著提高(P<0.05)。结论本研究建立的甲基供体营养质量指数与一碳单位代谢明显相关,可用于综合评价孕妇甲基供体膳食质量,未来仍需进一步验证其有效性。

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	李妞妞
	崔育梅
	滕越
	董珊
	鹿璐
	胡蕊
	孙京
	朱文丽
	潘丽娜
	蒋伟
	曾小玲
	梁滨

关键词 ：孕妇, 甲基供体营养素, 膳食质量, 一碳单位代谢

Abstract：Objective To develop and assess methyl-donor nutritional quality index in Chinese pregnant women.Methods A total of 218 pregnant women at 24 to 30 weeks of gestation were recruited on a voluntary basis from Beijing and Shandong province of China with the help of local maternal and child health institutions. Methyl-donor nutrients assessment was oriented to build the methyl-donor nutritional quality index (MNQI) for comprehensive evaluation of methyl donor intake, including daily dietary intake of protein, folic acid, vitamin B₂, vitamin B₆, vitamin B₁₂, and zinc. Maternal dietary intake was assessed using the 3-day food record, and calculated to get daily mean nutrients intakes. Fasting venous blood of each subject was collected during 24-30 weeks of gestation to measure erythrocyte folate, serum homocysteine and serum vitamin B₁₂. The sociodemographic characteristics were investigated by a self-administered questionnaire.Results In this survey, the intake deficiency of protein, folate, vitamin B₂, vitamin B₆ and vitamin B₁₂ were 26.8%, 64.1%, 50.2%, 73.7%, and 58.9%, respectively. The mean and medium of their MNQI scores were 4.89±2.18 and 5 (P25~P75:3~7). The MNQI score was positively correlated with erythrocyte folate level (P<0.05), and was negatively correlated with serum homocysteine level (P<0.05). Moreover, 38.7% of women had good methyl donor intake (MNQI≥6). The MNQI scores of women with higher per capita monthly income (≥6001 RMB/month) were significantly higher than those with 3001~6000 RMB/month (P<0.05).Conclusion In this study, we have a methyl donor nutritional quality index (MNQI) which could be used to comprehensively evaluate the quality of methyl donor diet, but its effectiveness still needs to be further verified.

Key words： Pregnant women Methyl donor nutrients Dietary quality One-carbon metabolism

收稿日期: 2021-03-30

ZTFLH:

R17

基金资助:湖南省乳业国际科技创新合作基地-湖南省科技创新平台与人才计划(2018WK4016)

通讯作者: 朱文丽(zhuwenli@bjmu.edu.cn)

引用本文:

李妞妞, 崔育梅, 滕越, 董珊, 鹿璐, 胡蕊, 孙京, 朱文丽, 潘丽娜, 蒋伟, 曾小玲, 梁滨. 孕期甲基供体营养质量指数的建立与评价[J]. 中国生育健康杂志, 2022, 33(5): 407-414. LI Niuniu, CUI Yumei, TENG Yue, DONG Shan, LU Lu, HU Rui, SUN Jing, ZHU Wenli, PAN Lina, JIANG Wei, ZENG Xiaoling, LIANG Bin. Development and assessment of methyl-donor nutritional quality index in pregnant women. Chinese Journal of Reproductive Health, 2022, 33(5): 407-414.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2022/V33/I5/407

1 Sae-Lee C,Corsi S,Barrow TM,et al.Dietary intervention modifies DNA methylation age assessed by the epigenetic clock.Mol Nutr Food Res,2018,62:1800092.
2 吴蒙蒙,杨凡.孕期甲基供体营养素与子代DNA甲基化关系的研究进展.中国当代儿科杂志,2017,19:601-606.
3 McKee SE,Reyes TM.Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition:considerations for future research.Nutr Rev,2018,76:497-511.
4 De-Regil LM,Peña-Rosas JP,Fernández-Gaxiola AC,et al.Effects and safety of periconceptional oral folate supplementation for preventing birth defects.Cochrane Database Syst Rev,2015:D7950.
5 Fekete K,Berti C,Trovato M,et al.Effect of folate intake on health outcomes in pregnancy:a systematic review and meta-analysis on birth weight,placental weight and length of gestation.Nutr J,2012,11:75.
6 McGee M,Bainbridge S,Fontaine-Bisson B.A crucial role for maternal dietary methyl donor intake in epigenetic programming and fetal growth outcomes.Nutr Rev,2018,76:469-478.
7 杨月欣.中国食物成分表第6版第1册.北京:北京大学医学出版社,2018.
8 杨月欣.中国食物成分表第6版第2册.北京:北京大学医学出版社,2019.
9 中国医药教育协会临床合理用药专业委员会等.中国临床合理补充叶酸多学科专家共识.中国医学前沿杂志(电子版),2020,12:19-37.
10 孔娟.高同型半胱氨酸血症诊疗专家共识.肿瘤代谢与营养电子杂志,2020,7:283-288.
11 吴宝娟,尹慧琴.血清同型半胱氨酸、红细胞叶酸和维生素B_(12)水平预测不良妊娠的作用分析.中国妇幼保健,2020,35:2780-2782.
12 陶艳,周瑜,陈谦明.维生素B12缺乏口腔表征的研究进展.国际口腔医学杂志,2019,46:78-83.
13 Palacin-Arce A,Monteagudo C,Beas-Jimenez JDD,et al.Proposal of a Nutritional Quality Index (NQI) to evaluate the nutritional supplementation of sportspeople.Plos One,2015,10:e125630.
14 中国营养学会.中国居民膳食营养素参考摄入量2013版.北京:科学出版社,2014.
15 Day CR,Kempson SA.Betaine chemistry,roles,and potential use in liver disease.Biochimica et Biophysica Acta (BBA)-General Subjects,2016,1860:1098-1106.
16 Kalhan SC.One carbon metabolism in pregnancy:Impact on maternal,fetal and neonatal health.Mol Cell Endocrinol,2016,435:48-60.
17 Robinson JL,Bartlett RK,Harding SV,et al.Dietary methyl donors affect in vivo methionine partitioning between transmethylation and protein synthesis in the neonatal piglet.Amino Acids,2016,48:2821-2830.
18 ACOG Practice Bulletin No.189:Nausea and vomiting of pregnancy.Obstet Gynecol,2018,131.
19 Barnabé A,Aléssio ACM,Bittar LF,et al.Folate,Vitamin B12 and Homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center.Nutr J,2015,14:19.
20 毛宝宏,王燕侠,李静,等.兰州城区孕妇膳食维生素及微量元素摄入状况调查与评价.中国妇幼卫生杂志,2020,11:10-16.
21 郭华棋.围孕期叶酸摄入方式对早产、低出生体重和小于胎龄儿的影响研究.兰州:兰州大学,2018.
22 Liu J,Gao L,Zhang Y,et al.Plasma folate levels in early to mid pregnancy after a nation-wide folic acid supplementation program in areas with high and low prevalence of neural tube defects in China.Birth Defects Res A Clin Mol Teratol,2015,103:501-508.
23 陈甘讷,蒋敏,黄伟雯,等.围孕期叶酸补充情况及其对妊娠结局影响.中华疾病控制杂志,2021,25:160-164.
24 王素芳.孕期增补叶酸对子代生长发育影响的出生队列研究.合肥:安徽医科大学,2017.
25 宫晓丽,魏瑗,赵扬玉.胆碱与胎儿生长发育的关系相关研究进展.中国妇产科临床杂志,2021,22:106-108.
26 湛永乐,陈云利,石英杰,等.孕期膳食摄入频率变化对抑郁影响的前瞻性队列研究.中国公共卫生,2019,36:1-6.
27 王杰等.中国居民营养与健康状况监测报告(2010-2013)之中国孕妇乳母营养与健康状况第1版.北京:人民卫生出版社,2020.
28 Finkelstein JL,Layden AJ,Stover PJ.Vitamin B-12 and Perinatal Health.Adv Nutr,2015,6:552-563.
29 Krishnaveni GV,Hill JC,Veena SR,et al.Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.Diabetologia,2009,52:2350-2358.
30 Zhou P,Hua H,Yan Z,et al.Diagnostic value of oral "beefy red" patch in vitamin B12 deficiency.Ther clin Risk Manag,2018,14:1391-1397.
31 Tucker KL,Rich S,Rosenberg I,et al.Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study.Am J Clin Nutr ,2000,71:514-522.
32 徐万洲,李迪,吴青,等.华裔中年女性每日总维生素B12摄入量与焦虑症的关系.安徽医药,2020,24:2527-2531.
33 Sukumar N,Rafnsson SB,Kandala NB,et al.Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight:a systematic review and meta-analysis.Am J Clin Nutr,2016,103:1232-1251.
34 Watanabe F,Bito T.Vitamin B(12) sources and microbial interaction.Exp Biol Med,2018,243:148-158.