Abstract:Objective To explore the effect of maternal blood interferon-inducible protein 10 (IFN-yinducible protein 10, IP10) on the risk of infant eczema and the role of delivery mode in infant eczema. Methods A prospective cohort study design was used. There were 890 mother-child pairs who joined the Born in Guangzhou Cohort Study (BIGCS) from January 2015 to December 2016. We collected maternal peripheral blood at 14-27 weeks of pregnancy and detected the concentration of IP10 in the blood. The eczema information of children within 1 year of age was collected by questionnaires filled out by their parents. Restricted cubic spline plots and log-binomial regression models were used to analyze the relationship between the levels of IP10 in maternal peripheral blood during pregnancy and the occurrence of infants' eczema as well as the interaction between delivery mode and maternal blood IP10 during pregnancy after adjusting for potential confounding factors (gestational diabetes, hypertension during pregnancy, maternal allergy history, tobacco exposure during pregnancy, pre-pregnancy BMI). Results The median IQR of IP10 in maternal peripheral blood during pregnancy was 104.53(62.94, 184.06)pg/mL. The proportion of infants' eczema was 20.0%. The regression model analysis of IP10 as a linear variable showed that the level of IP10 was associated with an increased risk of infants' eczema in the offspring(adjusted RR:1.51,95% CI:1.02-2.24). Compared with lowest IP10 levels, pregnant women with highest IP10 levels have an increased risk of infant eczema in their offspring(adjusted RR:1.58,95% CI:1.09-2.29). We did not find any interaction between delivery mode and maternal blood IP10 during pregnancy on infantile eczema (P=0.06). Conclusion Inflammatory factor IP10 during pregnancy affects the risk of eczema in infants. The interaction between delivery mode and IP10 in infantile eczema has not been observed yet. The role of delivery mode and other inflammatory factors during pregnancy in the association of infant eczema still needs further research.
邓莉婷, 孔少敏, 刘慧慧, 何健荣, 沈松英, 李宇思, 林珊珊, 邱琇. 孕期母血干扰素诱导蛋白10浓度与婴儿期湿疹的关系及分娩方式对其作用的影响[J]. 中国生育健康杂志, 2022, 33(4): 319-323.
DENG Liting, KONG Shaomin, LIU Hiuhiu, HE Jianrong, SHEN Songying, LI Yusi, LIN Shanshan, QIU Xiu. Effect of IP10 concentration during pregnancy on eczema in infancy and the effect of mode of delivery on its relationship. Chinese Journal of Reproductive Health, 2022, 33(4): 319-323.
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