儿童Alport综合征合并急性链球菌感染后肾小球肾炎2例报道并文献复习

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (323 KB) HTML (23 KB)
输出: BibTeX | EndNote (RIS)

摘要 Alport综合征合是儿童最常见的遗传性肾小球疾病之一,急性链球菌感染后肾小球肾炎是儿童最常见的原发性肾小球疾病之一,二者临床过程和诊治明显不同。本文报道了2例以急性链球菌感染后肾小球肾炎起病,最终确诊合并Alport综合征的儿童患者,并对其临床特点、病理表现及诊治经过进行总结和报道。Alport综合征起病隐匿,而急性链球菌感染后肾小球肾炎临床表现较突出,二者可以合并发生,患儿常常以急性链球菌感染后肾小球肾炎起病,继而在随访及治疗过程中进一步发现Alport综合征。对于急性链球菌感染后肾小球肾炎恢复期患儿再次出现肉眼血尿或肾功能进行性恶化,应警惕有无合并Alport综合征等遗传性肾脏疾病的可能。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	崔洁媛
	张磊
	袁晓颖
	韩佩桐
	刘玲
	张东风
	李春珍

关键词 ：儿童, Alport综合征, 急性链球菌感染后肾小球肾炎

收稿日期: 2021-12-21

ZTFLH:

R72

通讯作者: 李春珍(lichunzhen@sina.com)

引用本文:

崔洁媛, 张磊, 袁晓颖, 韩佩桐, 刘玲, 张东风, 李春珍. 儿童Alport综合征合并急性链球菌感染后肾小球肾炎2例报道并文献复习[J]. 中国生育健康杂志, 2023, 34(2): 188-191.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2023/V34/I2/188

1 Kashtan CE,Ding J,Garosi G,et al.Alport syndrome:a unified classification of genetic disorders of collagen IV alpha345:a position paper of the Alport Syndrome Classification Working Group.Kidney Int,2018,93:1045-1051.
2 Pedrosa AL,Bitencourt L,Paranhos RM,et al.Alport Syndrome:a comprehensive review on genetics,pathophysiology,histology,clinical,and therapeutic perspectives.Curr Med Chem,2021,28:5602-5604.
3 Chauvet S,Berthaud R,Devriese M,et al.Anti-Factor B Antibodies and Acute Postinfectious GN in Children.J Am Soc Nephrol,2020,31:829-840.
4 Rodriguez-Iturbe B,Musser JM.The current state of poststreptococcal glomerulonephritis.J Am Soc Nephrol,2008,19:1855-1864.
5 Rodriguez-Iturbe B,Haas M.Post-Streptococcal Glomerulonephritis.In:Streptococcus pyogenes :Basic Biology to Clinical Manifestations.Oklahoma City(OK),2016.
6 Blyth CC,Robertson PW,Rosenberg AR.Post-streptococcal glomerulonephritis in Sydney:a 16-year retrospective review.J Paediatr Child Health,2007,43:446-450.
7 Barozzi S,Soi D,Intieri E,et al.Vestibular and audiological findings in the Alport syndrome.Am J Med Genet A,2020,182:2345-2358.
8 Halawani LM,Abdulaal MF,Alotaibi HA,et al.Development of Posterior Lenticonus Following the Diagnosis of Isolated Anterior Lenticonus in Alport Syndrome.Cureus,2021,13:e12970.
9 Fogo AB,Lusco MA,Najafian B,et al.AJKD Atlas of Renal Pathology:Alport Syndrome.Am J Kidney Dis,2016,68:e15-e16.
10 Kashtan CE,Gross O.Clinical practice recommendations for the diagnosis and management of Alport syndrome in children,adolescents,and young adults-an update for 2020.Pediatr Nephrol,2021,36:711-719.
11 Zhang Y,Bockhaus J,Wang F,et al.Genotype-phenotype correlations and nephroprotective effects of RAAS inhibition in patients with autosomal recessive Alport syndrome.Pediatr Nephrol,2021,36:2719-2730.
12 Chertow GM,Appel GB,Andreoli S,et al.Study Design and Baseline Characteristics of the CARDINAL Trial:A Phase 3 Study of Bardoxolone Methyl in Patients with Alport Syndrome.Am J Nephrol 2021,52:180-189.
13 Goka S,Copelovitch L,Levy Erez D.Long-term outcome among females with Alport syndrome from a single pediatric center.Pediatr Nephrol,2021,36:945-951.
14 Katsuma A,Nakada Y,Yamamoto I,et al.Long-term survival in Japanese renal transplant recipients with Alport syndrome:a retrospective study.BMC Nephrol,2018,19:249.
15 Mallett A,Tang W,Clayton PA,et al.End-stage kidney disease due to Alport syndrome:outcomes in 296 consecutive Australia and New Zealand Dialysis and Transplant Registry cases.Nephrol Dial Transplant,2014,29:2277-2286.
16 崔洁媛,张宏文.儿童肾病综合征合并Alport综合征2例报道并文献复习.中国生育健康杂志,2016,27:589-591,595.
17 崔洁媛,张宏文.儿童IgA肾病合并Alport综合征2例报告并文献复习.临床儿科杂志,2017,35:9-12.
18 Gillion V,Jadoul M,Aydin S,et al.ANCA vasculitis in a patient with Alport syndrome:a difficult diagnosis but a treatable disease!.BMC Nephrol,2017,18:105.
19 McDonnell T,Chukwu C,Wong C.Alport's syndrome with type 4 renal tubular acidosis.BMJ Case Rep,2017,31; 1-3.
20 王硕,黄建萍.以过敏性紫癜为首发表现的儿童急性链球菌感染后肾小球肾炎1例报道并文献复习.中国医刊,2019,54:222-224.
21 Kuniyoshi Y,Kamura A,Yasuda S,et al.Post-streptococcal acute glomerulonephritis complicated by gouty arthritis:a case report.Pediatr Rheumatol Online J,2015,13:24.