1 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)(下).中国实用内科杂志,2021,41:757-784. 2 Anna V,van der Ploeg HP,Cheung NW,et al.Sociodemographic correlates of the increasing trend in prevalence of gestational diabetes mellitus in a large population of women between 1995 and 2005.Diabetes Care,2008,31:2288-2293. 3 Ferrara A.Increasing prevalence of gestational diabetes mellitus:a public health perspective.Diabetes Care,2007,30 Suppl 2:S141-146. 4 Guariguata L,Linnenkamp U,Beagley J,et al.Global estimates of the prevalence of hyperglycaemia in pregnancy.Diabetes Res Clin Pract,2014,103:176-185. 5 Zhu Y,Zhang C.Prevalence of gestational diabetes and risk of progression to type 2 diabetes:a global perspective.Curr Diab Rep,2016,16:7. 6 Gao C,Sun X,Lu L,et al.Prevalence of gestational diabetes mellitus in mainland China:A systematic review and meta-analysis.J Diabetes Investig,2019,10:154-162. 7 Zhang X,Liao Q,Wang F,et al.Association of gestational diabetes mellitus and abnormal vaginal flora with adverse pregnancy outcomes.Medicine(Baltimore),2018,97:e11891. 8 Chen J,Wang Z,Wu W,et al.Clinical analysis of 2860 cases of diabetes in pregnancy:a single-center retrospective study.BMC Pregnancy Childbirth,2022,22:418. 9 谢幸,孔北华,段涛.妇产科学(第九版).人民卫生出版社,2018:106-108. 10 Kc K,Shakya S,Zhang H.Gestational diabetes mellitus and macrosomia:a literature review.Ann Nutr Metab,2015,66 Suppl 2:14-20. 11 刘莹颖. 妊娠期代谢性疾病与不良妊娠结局关系的前瞻性队列研究.北京大学医学部,2021. 12 Ornoy A,Reece EA,Pavlinkova G,et al.Effect of maternal diabetes on the embryo,fetus,and children:congenital anomalies,genetic and epigenetic changes and developmental outcomes.Birth Defects Res C Embryo Today,2015,105:53-72. 13 Bellamy L,Casas JP,Hingorani AD,et al.Type 2diabetes mellitus after gestational diabetes:a systematic review and meta-analysis.Lancet,2009,373:1773-1779. 14 Lind JM,Hennessy A,McLean M.Cardiovascular disease in women:the significance of hypertension and gestational diabetes during pregnancy.Curr Opin Cardiol,2014,29:447-453. 15 Shah BR,Retnakaran R,Booth GL.Increased risk of cardiovascular disease in young women following gestational diabetes mellitus.Diabetes Care,2008,31:1668-1669. 16 Bianco ME,Josefson JL.Hyperglycemia during pregnancy and long-term offspring outcomes.Curr Diab Rep,2019,19:143. 17 Farahvar S,Walfisch A,Sheiner E.Gestational diabetes risk factors and long-term consequences for both mother and offspring:a literature review.Expert Rev Endocrinol Metab,2019,14:63-74. 18 Hassani Zadeh S,Boffetta P,Hosseinzadeh M.Dietary patterns and risk of gestational diabetes mellitus:A systematic review and meta-analysis of cohort studies.Clin Nutr ESPEN,2020,36:1-9. 19 Bao W,Bowers K,Tobias DK,et al.Prepregnancy dietary protein intake,major dietary protein sources,and the risk of gestational diabetes mellitus:a prospective cohort study.Diabetes Care,2013,36:2001-2008. 20 Chen Q,Feng Y,Yang H,et al.A vitamin pattern diet is associated with decreased risk of gestational diabetes mellitus in Chinese women:Results from a case control study in Taiyuan,China.J Diabetes Res,2019,2019:5232308. 21 Obeid R,Heil SG,Verhoeven MMA,et al.Vitamin B12 intake from animal foods,biomarkers,and health aspects.Front Nutr,2019,6:93. 22 Paul L,Selhub J.Interaction between excess folate and low vitamin B12 status.Mol Aspects Med,2017,53:43-47. 23 Crider KS,Yang TP,Berry RJ,et al.Folate and DNA methylation:a review of molecular mechanisms and the evidence for folate's role.Adv Nutr,2012,3:21-38. 24 Li W,Tang R,Ma F,et al.Folic acid supplementation alters the DNA methylation profile and improves insulin resistance in high-fat-diet-fed mice.J Nutr Biochem,2018,59:76-83. 25 Naderi N,House JD.Recent developments in folate nutrition.Adv Food Nutr Res,2018,83:195-213. 26 Scaglione F,Panzavolta G.Folate,folic acid and 5-methyltetrahydrofolate are not the same thing.Xenobiotica,2014,44:480-488. 27 Maruvada P,StoverPJ,Mason JB,et al.Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid:a summary,and perspectives,from an NIH workshop.Am J Clin Nutr,2020,112:1390-1403. 28 Liu Q,Wei S,Lei J,et al.Periconceptionalfolate and gestational diabetes mellitus:a systematic review and meta-analysis of cohort studies.J Matern Fetal Neonatal Med,2021:1-10. 29 Kouroglou E,Anagnostis P,Daponte A,et al.Vitamin B12 insufficiency is associated with increased risk of gestational diabetes mellitus:a systematic review and meta-analysis.Endocrine,2019,66:149-156. 30 代晨阳. 妊娠期糖尿病孕妇外周血维生素B12水平和肠道菌群关系初探.暨南大学,2021. 31 Mursleen MT,Riaz S.Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population.Diabetes Metab Syndr,2017,11 Suppl 1:S141-146. 32 Maher A,Sobczyńska-Malefora A.The relationship between folate,vitamin B12 and gestational diabetes mellitus with proposed mechanisms and foetal implications.J Family Reprod Health,2021,15:141-149. 33 Saravanan P,Sukumar N,Adaikalakoteswari A,et al.Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes:a prospective UK cohort study(PRiDE study).Diabetologia,2021,64:2170-2182. 34 Sukumar N,Venkataraman H,Wilson S,et al.Vitamin B12 Status among Pregnant Women in the UK and Its Association with Obesity and Gestational Diabetes.Nutrients,2016,8:768. 35 Bailey RL,Pac SG,Fulgoni VL,3rd,et al.Estimation of total usual dietary intakes of pregnant women in the united states.JAMA Netw Open,2019,2:e195967. 36 Sukumar N,Rafnsson SB,Kandala NB,et al.Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight:a systematic review and meta-analysis.Am J Clin Nutr,2016,103:1232-1251. 37 Li Q,Zhang Y,Huang L,et al.High-dose folic acid supplement use from prepregnancy through midpregnancy is associated with increased risk of gestational diabetes mellitus:A prospective cohort study.Diabetes Care,2019,42:e113-e115. 38 Chen X,Zhang Y,Chen H,et al.Association of maternal folate and vitamin B12 in early pregnancy with gestational diabetes mellitus:A prospective cohort study.Diabetes Care,2021,44:217-223. 39 Li N,Jiang J,Guo L.Effects of maternal folate and vitamin B12 on gestational diabetes mellitus:a dose-response meta-analysis of observational studies.Eur J Clin Nutr,2022. 40 Wang L,Hou Y,Meng D,et al.Vitamin B12 and folate levels during pregnancy and risk of gestational diabetes mellitus:A systematic review and meta-analysis.Front Nutr,2021,8:670289. 41 Lai JS,Pang WW,Cai S,et al.High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus.Clin Nutr,2018,37:940-947. 42 Li S,Hou Y,Yan X,et al.Joint effects of folate and vitamin B12 imbalance with maternal characteristics on gestational diabetes mellitus.J Diabetes,2019,11:744-751. 43 Li S,Tian X,Wang Y,et al.Associations of maternal rs1801131 genotype in MTHFR and serum folate and vitamin B12 with gestational diabetes mellitus in Chinese pregnant women.Nutrients,2022,14:1169. 44 Jankovic-Karasoulos T,Furness DL,Leemaqz SY,et al.Maternal folate,one-carbon metabolism andpregnancy outcomes.Matern Child Nutr,2021,17:e13064. 45 Krishnaveni GV,Hill JC,Veena SR,et al.Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.Diabetologia,2009,52:2350-2358. 46 李倩. 围孕期叶酸服用与妊娠期糖尿病及妊娠期高血压疾病关联的队列研究.华中科技大学,2020.