Abstract：Objective To develop a local fetal growth curve that can be used as a reference by clinicians, researchers and public health policy makers. Methods We used data of singleton births between 2006 and 2011 from the Taiyuan Birth Surveillance System. Information on gestational age based on ultrasound estimates was available for 82.86% of the newborns. Gestational age calculated through the first day of last menstrual period and birth date was compared with ultrasound-estimated age to improve the estimate validity and reliability. Two-component Gaussian Mixture Models was used to identify the major distribution, and locally weighted scatter plot smoothing was used to smooth the curve. Results The resulting male and female curves provided smooth and biologically plausible means, standard deviations, and percentile cutoffs. The reference at low and high gestational ages was considerably robust than our previous reference. Compared with studies from other parts of the world, our reference was lower than those from the European and North America countries, but close to those from Asian countries. Conclusion This new sex-specific, population-based reference may help improve clinical assessment of growth in individual newborns, population-based surveillance of geographic and temporal trends in birth weight by gestational age, and evaluation of clinical or public health interventions that maim to enhance fetal growth.
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