Abstract：Objective To investigate the status of vaccination in children with biliary atresia after Kasai surgery. Methods A retrospective study was conducted among 70 children diagnosed with biliary atresia and underwent Kasai surgery aged from 11 months to 3 years and 4 months in 2019-2022. There were 37 male cases and 33 female cases. Clinical characteristics, vaccination status and adverse reactions were analyzed. Children were grouped according to whether they were evaluated, and the liver function indicators and vaccination rates were compared between two groups. Results Among 70 cases, the vaccination rates with Kasai preoperatively (excluding vaccination at birth) and postoperatively were 11.4% and 72.8% respectively. 86.3% of patients resumed vaccination after 6 months postoperatively. 78.4% of children after Kasai surgery had elevated transaminases when they resumed immunization. 82.4% of them had abnormal bile acids, and 56.9% of patients took drugs when the vaccination was resumed. None of children had serious adverse reactions after vaccination. After being evaluated by clinicians in special vaccination clinic (operation time from December 2019 to December 2020 vs. January 2021 to June 2022), the vaccination rate of children after Kasai surgery increased significantly [46.7% vs. 92.5%,P<0.05]. Conclusion Our study revealed that the vaccination rate of children with biliary atresia after surgery is low, and the vaccination delay is significant. Timely vaccination should be safe and necessary when the condition is stable, after evaluation for those children.
刘涛, 韩英, 胡丹丹, 朱俐燕. 胆道闭锁葛西术后儿童的预防接种观察与分析[J]. 中国生育健康杂志, 2023, 34(6): 539-542.
LIU Tao, HAN Ying, HU Dandan, ZHU Liyan. Analysis on vaccination of children with biliary atresia after Kasai surgery. Chinese Journal of Reproductive Health, 2023, 34(6): 539-542.
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