孕早期甲状腺过氧化物酶抗体阳性对妊娠的影响

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (651 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的观察孕早期单纯甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPO-Ab)阳性是否会增加孕产妇的妊娠期间并发症和不良妊娠结局。方法收集孕周≤13周且甲状腺功能正常孕妇的临床资料,以TPO-Ab为依据分为抗体阴性组(＜60 kU/L)和阳性组(≥60 kU/L),随访患者甲状腺功能的变化,比较两组患者妊娠结局的差异。结果 TPO-Ab阳性组患者TSH值[(1.3±0.7)mU/L]高于TPO-Ab阴性组[(1.1±0.6)mU/L],差异具有统计学意义。TPO-Ab阳性组产妇羊水过少(4.1%)、胎膜早破(15.7%)、产后出血(8.2%)的发生率均大于TPO-Ab阴性组(依次为0.8%、1.9%、0.9%),差异有统计学意义。TPO-Ab阳性组孕妇在孕早期(孕周＜13周)的LDL-TC[(1.9±0.6) mmol/L]低于TPO-Ab阴性组[ (2.1±0.7)mmol/L],而Alb[(38.6±3.9)g/L]高于TPO-Ab阴性组[(37.8±4.6)g/L],差异均有统计学意义。结论 TPO-Ab阳性产妇羊水过少、胎膜早破和产后出血的发生率明显增加,目前仍需大样本数据进一步探讨TPO-Ab阳性对妊娠期间并发症和妊娠结局是否存在其他不良影响。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	高红
	马晓莉
	张琳
	孙涛

关键词 ：妊娠, 甲状腺过氧化物酶抗体, 羊水过少, 胎膜早破, 产后出血

收稿日期: 2015-08-14

基金资助:首都医科大学附属北京妇产医院院内课题(fcyy201203)

引用本文:

高红, 马晓莉, 张琳, 孙涛. 孕早期甲状腺过氧化物酶抗体阳性对妊娠的影响[J]. 中国生育健康杂志, 2016, 27(2): 138-140.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2016/V27/I2/138

1 Cleary-Goldman J,Malone FD,Lambert-Messerlian G,et al.Mammal thyroid hypofuncfion and pregnancy outcome.Obstet Gynecol,2008,112:85-92.
2 Haddow JE,Cleary-Goldman J,McClain MR,et al.Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery.Obstet Gynecol,2010,116:58-62.
3 Karakosta P,Alegakis D,Georgiou V,et al.Thyroid dysfunction and autoantibodies in early preganancy are associated with increased risk of gestational diabetes and adverse birth outcomes.J Clin Endocrinol Metab,2012,97:4464-4472.
4 Matejkova-Behanova M.Latent autoimmune diabetes in adults(LADA) and autoimmune thyroiditis.Endocr Regu,2001,35:167-172.
5 Abbassi-Ghanavati M,Casey BM,Spong CY,et al.Pregnancy outcomes in women with thyroid peroxidase antibodies.Obstet Gynecol,2010,116:381-386.
6 Mnnist T,Vrsmki M,Pouta A.et a1.Perinstal outcome of children born to mothers with thyroid dysfunction or antibodies:a prospective population-based cohort study.J Clin Endocrinol Metab,2009,94:772-779.
7 Li Y,Shan Z,Teng W,et al.Abnormalities of matemal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months.Clin Endocrinol(Oxf),2010,72:825-829.
8 Bhattacharyya R,Mukherjee K,Das A,et al.Anti-thyroid peroxidase antibody positivity during early pregnancy is associated withpregnancy complications and maternal morbidity in later life.J Nat Sci Biol Med,2015,6:402-405.
9 徐艳红,吴艺捷,罗越,等.孕妇血清甲状腺过氧化物酶抗体阳性对妊娠结局的影响.中华内分泌代谢杂志,2012,28:377-381.
10 Yoneyama Y,Suzuki S,Sawa R,et al.Changes in the proportion of T helper 1 and T helper 2 cells in cord blood after prematurerupture of membranes.Arch Gynecol Obstet,2003,267:217-220.
11 Khan FA,Al-Jameil N,Khan MF,et al.Thyroid dysfunction:an autoimmune aspect.Int J Clin Exp Med,2015,8:6677-6681.
12 张仁凤.Surviving,caspase-3,AQP1与妊娠晚期羊水过少相关性研究.中国医药导报,2012,14:661-662.
13 黄凌宁,杨立勇,张声,等.桥本甲状腺炎中TRAIL、caspase-3的表达与甲状腺过氧化物酶抗体相关性研究.2011,24:160-161.
14 Mnnist T,Vrsmki M,Pouta A.et a1.Thyroid dysfuncfion and autoantibodies during pregnancy as predictive factors of pregnancy compUcations and matemal morbidity in later life.J Clin Endocrinol Metab,2010,95:1084-1094.
15 Montaner P,Juan L.Campos R,et al.Is thyroid autoimmunity associated with gestational diabetes mellitus?Membolism,2008,57:522-525.
16 Feki M,Omar S,Menif O,et al.Thyroid disorders in pregnancy:Frequency and association with selected diseases andobstetrical complications in Tunisian women.Clin Bioehem,2008,41:927-931.
(