<i>VEGFA</i>基因多态性与小于胎龄儿的易感性

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摘要目的探讨血管内皮细胞生长因子A(VEGFA)基因多态性与小于胎龄儿(SGA)易感性。方法采用巢氏病例对照研究设计,选取2013年5月到2014年9月马鞍山优生优育队列中分娩SGA的母亲183例和分娩适于胎龄儿(AGA)的母亲298例。对母血VEGFA基因上7个功能性位点(rs2010963、rs833061、rs10434、rs1570360、rs3025020、rs3025040、rs3025053)进行基因分型。应用多因素Logistic回归法分析不同遗传模型下各位点与SGA发病风险之间的相关性。结果多因素Logistic回归分析显示,调整母亲年龄、文化程度、吸烟、饮酒及家庭月收入后,与VEGFA rs2010963 CC基因型携带者相比,GC基因型(OR=1.94,95% CI=1.12～3.35)和G等位基因携带者(OR=1.69,95% CI=1.01～2.83)分娩SGA的风险显著增加。进一步控制母亲孕前BMI和父亲BMI后,以上结果仍有显著性。但经错误发现率(FDR)校正后,显著性消失。结论携带VEGFA rs2010963 G等位基因的孕妇分娩SGA的风险是否增高需要更大样本的验证。

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	刘慧
	邵珊珊
	黄锟
	严双琴
	刘雨薇
	朱鹏
	郝加虎
	陶芳标

关键词 ：小于胎龄儿(SGA), 遗传多态性, 血管内皮细胞生长因子A(VEGFA)

收稿日期: 2020-09-29

ZTFLH:

R17

基金资助:安徽医科大学2016年度博士科资助(XJ201620)

通讯作者: 邵珊珊(shaoshsh@126.com)

引用本文:

刘慧, 邵珊珊, 黄锟, 严双琴, 刘雨薇, 朱鹏, 郝加虎, 陶芳标. VEGFA基因多态性与小于胎龄儿的易感性[J]. 中国生育健康杂志, 2022, 33(4): 347-349.

链接本文:

http://cjrh.bjmu.edu.cn/CN/ 或 http://cjrh.bjmu.edu.cn/CN/Y2022/V33/I4/347

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